Young women with disabilities face unique barriers in the transition from school to adulthood, yet very few studies have examined the effectiveness of gender-specific career interventions. Using an intent-to-treat analysis, this study tested the efficacy of the Paths 2 the Future (P2F) career development curriculum to produce beneficial impacts as compared to business-as-usual career and transition services within a clustered, school-randomized trial. The sample included 366 young women with disabilities enrolled in 26 high schools. Controlling for student and school characteristics, multilevel growth models showed that young women in the P2F intervention schools grew in career development skills at a greater rate relative to those in the control schools. Findings suggest that P2F was effective in promoting individual student differences in career development skills for young women with disabilities and support the need for further research examining effectiveness of gender-specific career interventions in special education.