Nonacademic skills related to college and career readiness (CCR) have become more prevalent in the literature as proposed conceptual models and frameworks, yet little empirical research exists in their support. We employed latent variable modeling to empirically test a previously proposed six-domain framework of CCR for adolescents with and without disabilities. Results support four specific factors of CCR: Academic Engagement, Critical Learning Processes, Mind-Set, and Transition Knowledge. Using a bifactor model, we confirmed one general factor (CCR) and one specific factor (Transition Knowledge), established measurement invariance on the basis of disability, and found latent mean differences between these groups; students without disabilities had greater overall CCR and transition knowledge. Findings support the use of a CCR measurement model with two potential factor scores in future research and practice and may inform efforts to measure CCR nonacademic skills.