Scientific evidence should guide the selection of practice for individuals with disabilities. Scientific evidence, however, must be trustworthy to move special education toward greater empirical certainty and more effective policies and practices. Transparency, openness, and reproducibility increase the trustworthiness of evidence. We propose that researchers in special education adopt emerging open-science reforms, such as preprints, data and materials sharing, preregistration of studies and analysis plans, and Registered Reports. Adoption of these practices will require shifts in cultural norms, guidelines, and incentives. We discuss how adopting open-science practices can advance the quality of research and, consequently, policy and practice in special education.