This article introduces a framework for the remediation of number combination (NC) deficits. Research on the remediation of NC deficits is summarized, and research program studies are used to illustrate the 3 approaches to remediation. The Framework comprises a 2-stage system of remediation. The less intensive stage implementing 1 of 3 intervention approaches hypothesized to be most productive for a student uses a validated protocol while monitoring student response. The more intensive stage, which is reserved for nonresponders, involves integrating the 3 intervention approaches within a skills-based diagnostic-prescriptive scheme for individualizing intervention.