Elopement, or running away from supervised areas, is a dangerous and problematic behavior that compromises the safety of people with disabilities at disproportionately high rates. As such, it is paramount that teachers know how to respond to elopement during school to ensure student safety. Although general safety strategies may be helpful in preventing elopement, they fail to address the factors that trigger elopement. Recent advances in the assessment and treatment of elopement offer strategies that teachers can use to help treat elopement by first understanding why it occurs. We describe the common reasons elopement may occur, outline a systematic approach for assessment and treatment of elopement that teachers can use in school settings, and provide a strategy for maintaining treatment effects over time.